Antigen presentation by common variable immunodeficiency (CVID) B cells and monocytes is unimpaired

Autoimmunity and infection in common variable immunodeficiency (CVID).

Common variable immunodeficiency (CVID) is a heterogeneous group of diseases, characterized by primary hypogammaglobulinemia. B and T cell abnormalities have been described in CVID. Typical clinical features of CVID are recurrent airway infections; lymphoproliferative, autoinflammatory, or neoplastic disorders; and autoimmune diseases among which autoimmune thrombocytopenia (ITP) is the most co...

Clinical and Immunological Spectrum of Common Variable Immunodeficiency (CVID).

We have analysed data from 150 patients initially classified as having CVID. About 10% had laboratory abnormalities suggesting known single gene disorders (eg: hyper-IgM syndrome), and in a few a genetic defect has been confirmed. We have attempted to sub-classify the remaining patients by analysis of their circulating lymphocytes. B lymphocyte markers have been used to estimate the numbers of ...

clinical and immunological spectrum of common variable immunodeficiency (cvid)

we have analysed data from 150 patients initially classified as having cvid. about 10% had laboratory abnormalities suggesting known single gene disorders (eg: hyper-igm syndrome), and in a few a genetic defect has been confirmed. we have attempted to sub-classify the remaining patients by analysis of their circulating lymphocytes. b lymphocyte markers have been used to estimate the numbers of ...

بررسی وجود جهش در ژن b-cell maturation antigen (bcma) بیماران مبتلا به common variable immunodeficiency (cvid)

مقدمه: نقص ایمنی متغیر شایع (common variable immunodeficiency یا cvid)، فراوان ترین نارسایی ایمنی اولیه از نظر بروز علایم بالینی و مجموعه شرایط ناهمگنی است که با کمبود ارثی آنتی بادی (هایپوگاماگلوبولینمی) از حداقل دو ایزوتیپ ایمونوگلوبولین به همراه اختلال در بلوغ سلول های b و جهش سوماتیک، کاهش تعداد سلول های خاطره ی تعویض کلاس شده و نشده در گردش خون و اغلب با نبود پلاسماسل شناخته می شود. b-cell...

Co-existence of Common Variable Immunodeficiency (CVID) with Idiopathic Thrombocytopenic purpura (ITP)